This multicentre RCT included 337 patients with at least one venous leg ulcer present for more than six months. Patients were randomly allocated to either weekly administration of low-dose high-frequency ultrasound for up to 12 weeks plus standard care, or standard care alone.
The main outcome measure was time to healing of the largest leg ulcer and the researchers found no significant difference in this endpoint between the two groups (p = 0.61). Patients treated with ultrasound therapy experienced significantly more adverse events than those treated with standard care.
Watson JM, Kang'ombe AR, Soares MO et al. BMJ 2011; 342: d1092